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Once the xenograft tumors for the study of 2DG or BPTES treatment were established (when the tumor volume was ~50100 mm 3 ), the mice were randomly divided into six groups ( n = 5 mice per group) and treated with saline buffer (10% DMSO), 2DG (500 mg/kg/day) or BPTES (12.5 mg/kg/day), each with or without TRAIL (5 g/kg/day), via intraperitoneal injection three times a week for 33 days